Post-Doc Research Associate - Brouwer Lab
Company: UNC-Chapel Hill
Location: Chapel Hill
Posted on: April 1, 2026
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Job Description:
Position Summary A postdoctoral research position is available
immediately to investigate the utility of in vitro models (e.g.,
hepatic organoid 3D cell models, sandwich-cultured hepatocytes,
HuH-7 cells, membrane vesicle systems) to (1) predict the hepatic
disposition of drugs and metabolites in vivo, (2) predict the
impact of disease-mediated alterations in transport function on
hepatocellular accumulation and routes of excretion (canalicular
vs. basolateral) of anionic drugs/metabolites, and (3) examine
hepatic transporter trafficking and regulatory mechanisms. NIH
-funded research program to study the hepatic disposition of
xenobiotics utilizing in vitro model systems,
regulation/trafficking of transport proteins, and
cellular/molecular mechanisms responsible for hepatic structure and
function. Research includes but is not limited to: in vitro cell
culture experiments, transport assays, Western Blotting, cloning
and mutagenesis, immunohistochemical imaging and live cell imaging,
LC-MS/MS, maintaining the laboratory’s animal care and use and
radiation safety records in accordance with institutional, state,
and federal guidelines. Required Qualifications, Competencies, And
Experience Experience with cell culture and advanced molecular
biology/biochemistry techniques. Excellent communication skills and
ability to work independently as well as a member of an
interdisciplinary team are essential. Preferred Qualifications,
Competencies, And Experience Preference will be given to candidates
with expertise in pharmacokinetic modeling and simulation, and
drug-induced liver injury.
Keywords: UNC-Chapel Hill, Durham , Post-Doc Research Associate - Brouwer Lab, Science, Research & Development , Chapel Hill, North Carolina
