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Scientist - Automation

Company: Precision BioSciences
Location: Durham
Posted on: September 15, 2019

Job Description:

Precision Biosciences is seeking a Scientist to establish, integrate and optimize automation capabilities that drive platform-based screening and characterization of ARCUS nucleases. The Scientist will collaborate with various Precision Biosciences teams to develop and automate bioassays that enable the translation of nuclease activity into phenotypic data. The role will involve working with established cell lines, primary cells, stem cells and where required, organoid-based models. The generation of this in vitro information is an important step in the progression of ARCUS-based therapeutics from discovery to pre-clinical development. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Automate bioassays involved in the characterization of ARCUS nuclease activity: DNA and RNA isolation, processing/purification Cell-based experiments with read outs at the molecular level (DNA, RNA or protein) indel dose response assays with fluorescent analysis by FACS, PCR/digital PCR or ELISA Collaborate with discovery scientists to develop workflows, documentation and user information for assays utilizing automation: Assay design and optimization Technical protocols and SOPs Integration with laboratory information management systems for data capture, review and analysis Ensure automation equipment is well maintained and working to vendor specifications: Establish QC procedures Train staff in the use of equipment Schedule preventive maintenance and service calls as needed Monitor emerging automation trends and apply where appropriate to improve assay robustness, reproducibility and throughput Cultivate mammalian cells Maintain CHO KI, HEK 293, and other laboratory cell lines and frozen stocks Create, characterize, and maintain novel reporter cell lines Transfect and transduce mammalian cells Maintain accurate records in ELN system and assist in the organization and tracking of lab constructs, cell lines, and supplies Contribute to the generation of SOPs in support of pre-clinical data information Assist in general operation of the cell culture and molecular lab Monitoring/changing CO2 tanks Monitoring LN2 storage tank Ordering and stocking of lab consumables Disposal of Waste Report results to Therapeutic Discovery Team File reports for internal use and for partners Generate graphs, slides, protocols and other documents for partners Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Required: Education/Experience The Scientist should have a PhD, MSc or BSc with 6-10 years of relevant experience or equivalent training and experience in the following areas: Automation of bioassays (cell-based and biochemical) Automated liquid handling/dispensing platforms Troubleshooting of automation-related problems Equipment user interface-based programming Cell and Biochemical Assay development and optimization Preferred: Working knowledge of: Plasmid and genomic DNA isolation RNA isolation Molecular Cloning techniques for Vector construction PCR, qPCR DNA, RNA Transfection and Viral Transduction for expression in Eukaryotic Cells Systems Protein Characterization by Western, Flow Cytometry, and ELISA Bioinformatics (JAVA, R, Python, SQL/Oracle) Travel Requirements Minimal travel is required for this position Location This position is located at the main headquarters located in Durham, NC and is required to physically be and work in the office, in order to be most effective, and at managers discretion. Precision BioSciences is dedicated to improving life through its proprietary genome editing platform, ARCUS. Precision BioSciences leverages ARCUS in the development of its product candidates which are designed to treat human diseases and create healthy and sustainable food and agriculture solutions. Precision BioSciences is actively developing product candidates in three innovative areas: allogeneic CAR T immunotherapy, in vivo gene correction, and food. Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

Keywords: Precision BioSciences, Durham , Scientist - Automation, Other , Durham, North Carolina

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