DurhamRecruiter Since 2001
the smart solution for Durham jobs

Scientist, Process Science (Analytical)

Company: AveXis Inc.
Location: Durham
Posted on: September 15, 2019

Job Description:

Overview Ready to join a team committed to developing and commercializing gene therapies for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science, starting with our proprietary gene therapy for the treatment of spinal muscular atrophy (SMA). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission. AveXis, a Novartis company, is dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product is a proprietary gene therapy approved by the US Food and Drug Administration for the treatment of pediatric patients with SMA. In addition to developing a treatment for SMA, AveXis also plans to develop other novel treatments for rare neurological diseases, including Rett syndrome and a genetic form of amyotrophic lateral sclerosis caused by mutations in the superoxide dismutase 1 (SOD1) gene. AveXis is seeking an experienced and exceptional Scientist to join the dynamic and growing analytical team to establish bioassays suitable for lot disposition and characterization of gene therapy drug products and substances. The individual will play a crucial role for the development and optimization of novel potency and other functional assays in a team environment. In addition, he/she will participate in method qualification/validation in a cGMP setting and may be involved in the method transfer to internal and/or external QC laboratories. Responsibilities will also include execution of routine assays and supporting lab operation. Successful candidate may have expertise with AAV analysis and will be adept and perceptive with passion for new technology and science. Responsibilities Perform experiments in support of assay development using variety of techniques covering cell biology, biochemistry and molecular biology such as immunocytochemistry, western blot, PCR, flow cytometry, and immunoprecipitation. Optimize and troubleshoot assays using variety of platforms including but not limited to ELISA, MSD, high-content imaging and luminescent/fluorescent plate reader in support of developing release and characterization assays for gene therapy products. Thoroughly document optimization and troubleshooting processes. Actively engage in planning and designing of assays/experiments and take ownership of assays/experiments one is performing by understanding the purpose, rigidly following through every step of execution, thoroughly analyzing data and ensuring the data quality. Play an important role in qualifying and validating novel assays. Help documenting assay development, qualification and validation processes as well as SOPs. Collaborate with R&D for knowledge transfer during assay development and work closely with QC for method transfer. Be actively involved (both as trainee and trainer) in cross-training of lab personnel. Qualifications B.S, M.S, or PhD in biology discipline is required. Minimum 5 years of biopharma industry experience is required for B.S, minimum 3 years of biopharma industry experience is required for M.S., and minimum 2 years of biopharma industry experience is required for PhD. Basic understanding of regulatory agency guidance such as FDA, ICH and EMA and hand-on experience is a significant plus. Demonstrated track record of successfully optimizing and executing AAV quantification using various assay platforms including but not limited to HPLC, ELISA, MSD, ELISpot, qPCR, ddPCR and high-content imaging in 96/384 well plate setting. Broad experiences in cellular, biochemical and molecular biological methods including but not limited to immunostaining, flow cytometry, protein gel, Western blot, PCR and qPCR. Enjoy learning and challenges. Especially, must be able to learn new instrument and master their software quickly. Ability to work in a fast-paced small but growing team environment and to prioritize work from multiple projects. Must be highly reliable and goals/deadlines oriented. Intelligent individual who respects others and is open to new/different ideas. Must have exceptional organizational skills. Excellent written and verbal communication skills. The level of this position will be based on the final candidate's qualifications. Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice. AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status. #LI-JH1

Keywords: AveXis Inc., Durham , Scientist, Process Science (Analytical), Other , Durham, North Carolina

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Other Other Jobs


Bid On Local Remodeling Jobs - Reach New Customers In Your Area
Description: Over 25 million homeowners have trusted HomeAdvisor 1800Contractor to help them find quality professionals with the expertise to turn their home improvement
Company: HomeAdvisor
Location: Lynchburg
Posted on: 09/20/2019

Reading Tutors - VA
Description: Smart Beginnings DP seeks experienced reading
Company: Smart Beginnings DP
Location: Danville
Posted on: 09/20/2019

OTR CDL A Truck Drivers - 1+ yrs Tractor-Trailer EXP REQUIRED!
Description: Cox Transportation Services, Inc. is now hiring OTR CDL A Truck Drivers
Company: Cox Transportation Services
Location: Danville
Posted on: 09/20/2019


Benefit Rep
Description: We have an A Rating with the Better Business Bureau. We are a 25 year old company seeking people who are
Company: Living Healthy
Location: Greenville
Posted on: 09/20/2019

Invest in Business Ownership: Own your own Franchise, starting at a $30k investment
Description: Instead of getting another
Company: FranchiseHelp
Location: Rocky Mount
Posted on: 09/20/2019

Diesel Mechanic Technician - $3K Sign-on Bonus!! First Shift, Mon to Fri!
Description: Post-secondary vocational education strongly preferred Must have minimum tool requirement Must have a valid driver's license Valid CDL license A is highly desired mandatory in some locations Must possess (more...)
Company: Ryder
Location: Wilson
Posted on: 09/20/2019

CDL-A Driver - Paid Orientation & Tuition Reimbursement!
Description: US Xpress Has High Paying Jobs For CDL A Truck Drivers. U.S. Xpress is now offering an EXTRA 12,000 IN YOUR FIRST YEAR for experienced drivers 1000 PAID EVERY MONTH Ask about our great DEDICATED opportunities (more...)
Company: US Xpress
Location: Chapel Hill
Posted on: 09/20/2019

Benefit/Training Specialist
Description: We are currently interviewing peopleTODAYto work at home To Request an Interview, please visit http://www.freedomathometeam.com/Christyh40 We provide free training through the internet or through telephone (more...)
Company: Ameriplan
Location: Burlington
Posted on: 09/20/2019

OTR CDL A Team Truck Drivers - Competitive Pay!
Description: Cox Transportation Services, Inc. is now hiring OTR CDL A Truck Drivers
Company: Cox Transportation Services
Location: Chapel Hill
Posted on: 09/20/2019

U.S. Xpress is excited to announce Straight Pay- A New Way to Team Pay!
Description: We're changing the game on team pay and making it easier for our
Company: USXpress
Location: Danville
Posted on: 09/20/2019

Log In or Create An Account

Get the latest North Carolina jobs by following @recnetNC on Twitter!

Durham RSS job feeds