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Manufacturing Associate III, AAV

Company: Precision Biosciences
Location: Durham
Posted on: September 25, 2022

Job Description:

Summary

The Manufacturing Associate III (AAV), will be part of a team responsible for execution of the tech transfer and subsequent CGMP manufacturing of viral vector therapies for use in clinical trials. Additional responsibilities include set-up, operation and cleaning of equipment, equipment and process monitoring and troubleshooting, ordering materials, authoring technical documents, training and mentoring junior staff, leading quality, and process improvement projects, and collaborating with functions supporting cGMP manufacture.

The ideal candidate will also have a strong passion and curiosity for science and gene therapy with the desire to contribute individually and collectively in a dynamic, fast-paced environment.

Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

* Operate Bioprocess Equipment under adherence to cGMPs, OSHA regulations and company policies
* Inform management on status of all projects, any deviation, and significant findings
* Setup, test, and adjust manufacturing equipment if needed
* Effectively troubleshoot equipment and processing problems
* Document manufacturing activities clearly and accurately
* Draft and revise SOPs and Batch Records, as necessary
* Monitor critical process parameters
* Maintain room material inventory
* Proficiency with compliance; adherence to standard operating procedures , batch record, and good documentation practices
* Clean and sterilize parts and equipment as needed
* Collect hazardous and non-hazardous waste in correctly labeled barrels or containers

Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Required:

* BS degree in Chemical Engineering, Biochemical Engineering, Chemistry, Biology or related discipline with 5+ years of related experience or equivalent combination of education and experience
* Experience with one or more skills associated with upstream OR downstream manufacturing of biologics
* Prior manufacturing experience in the pharmaceutical or biotechnology industry
* Broad knowledge of biotech manufacturing process and equipment including depth and tangential flow filtration, column chromatography, protein purification, formulation, aseptic technique, filter integrity testing, formulation, sterile filtration, and fill/finish operations
* Meticulous, detail oriented, and analytical
* Highly motivated with excellent organizational, communication and interpersonal skills
* Willing to work independently and as part of a multi-disciplinary team
* Ability to understand, apply, and evaluate basic chemistry, biology and scientific principles as appropriate for the position
* Excellent communication and interpersonal skills (both verbal and technical)
* Team player, able to work with others

Preferred:

* Gene Therapy manufacturing experience
* Large scale purification experience
* Experience working in cGMP purification manufacturing

Travel Requirements

No travel is anticipated for this position

Location

This is an office-based position located at the MCAT facility in RTP, NC.

Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS - genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com

Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

Keywords: Precision Biosciences, Durham , Manufacturing Associate III, AAV, Other , Durham, North Carolina

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