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Principal Scientist

Company: Amazon Workforce Staffing
Location: Durham
Posted on: September 17, 2020

Job Description:

Principal Scientist, Downstream Process Development Lead Company: Sigma Xi, The Scientific Research Society

Location: Cambridge

Posted on: September 12, 2020

Job Description:

Sigma Xi, The Scientific Research Society's Career CenterPrincipal Scientist, Downstream Process Development Lead

SB Principal Scientist, Downstream Process Development LeadSolid’s Start : Solid is the English translation of Eytan, theHebrew name of Solid’s co-founders Ilan and Annie Ganot’s son,Eytani, who was diagnosed with Duchenne muscular dystrophy(Duchenne) in 2012 at the age of 3. Unsatisfied with the existingDuchenne treatment landscape, the Ganots built a disease-focusedcompany with the people and potential to advance innovative sciencequickly and responsibly.

Solid’s Culture: Much of what you can learn about Solid and ourculture can be found in our name. We come to work each day for theDuchenne community, and that community is our family. We have acollective strength and determination that propels us to embraceinnovation and challenge the status quo because central to all thatwe do is the unwavering commitment to advance meaningful therapiesfor the Duchenne community. We are a fiercely passionate andcommitted team, driven to collaborate with thoughtfulness andrespect. We value exceptional skills, scientific curiosity,entrepreneurial spirit, diversity and adaptability.#TogetherWeAreSolid in our mission to find a cure for Duchennemuscular dystrophy and we will not stop until we’ve done it.

Summary of role:

Solid Biosciences is seeking an experienced Principal Scientistto join our Process Development team and contribute to thedevelopment of our downstream viral vector manufacturing processes.This individual will join a dynamic and motivated team to developand characterize unit operations in support of a mid to late stageviral vector program, as well as tech transfer of the process tothe clinical/commercial manufacturing team.

Requirements

The successful candidate will be responsible for leading a teamof scientists and engineers on the design and execution ofexperiments supporting troubleshooting, development,characterization, scale-up, and transfer of the downstreammanufacturing processes. They will also be responsible forevaluation and implementation of new and existing technology.

What's in it for you?

Opportunity to:

Oversight, scheduling, planning and reviewing of viral vectorprocess development and tech transfer experiments in the PD labrelated to all downstream processes and in-process analytics, toinclude process optimization and problem-solving processes andequipment

Lead a team of scientists and engineers focused on developmentand optimization of viral vector purifications processes

Identify, evaluate, and implement new and existing technologiesto improve process efficiency, control, and understanding

Coordinates with Upstream PD and analytical development onmultiple projects simultaneously

Apply DOE and other advanced statistical techniques to designexperiments related to process development, characterization, andscale-up

Authoring of high-quality documents, including technicalreports, presentations, SOPs, experimental protocols, andregulatory filings

Develops and mentor direct reports through challengingassignments and providing constructive feedback, goal setting andmonitoring performance on a routine and ensuring that overallproject goals are on track

Self-motivated, accountable, inquisitive, with excellentorganizational and communication skills

Flexibility to switch between projects

Ability to lead/manage junior team members

What we need from you:

Ph.D. in Chemical Engineering or related field and 6+ years ofexperience, Master’s or a Bachelor’s degree in the same field with10+ years of experience in downstream process development

Strong scientific skills and process development experienceworking with gene therapy products

Proven expertise in all downstream purification conceptsincluding chromatographic separation, centrifugation, filtration,and viral inactivation/removal

Excellent technical, organizational, interpersonal,collaborative, and verbal/written communication skills - includingexcellent presentation skills and the ability to communicate withemployees at all levels including senior management

Strong understanding of GxPs, process characterization, andtechnology transfer

Ability to manage, analyze, and interpret complex experimentaldata

Ability to apply engineering fundamentals to process design andscale-up

Ability to apply statistical tools for process monitoring,experimental design, and data analysis

Travel Commitment:

Some travel may be required

Job Information

Job ID: 54026085

Location:

Cambridge, Massachusetts, United States

Position Title: Principal Scientist, Downstream ProcessDevelopment Lead

Company Name: Solid Bioscience

Job Function: Scientist

Job Type: Full-Time

Job Duration: Indefinite

Min Education: BA/BS/Undergraduate

Min Experience: Over 10 Years

Required Travel: 0-10%

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PO Box 13975 3200 Chapel Hill Nelson Blvd., Suite 300 ResearchTriangle Park, North Carolina 27709 (800) 243-6534 or (919)549-4691

Keywords: Sigma Xi, The Scientific Research Society, Cambridge , Principal Scientist, Downstream Process Development Lead, Other , Cambridge, Massachusetts

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Keywords: Amazon Workforce Staffing, Durham , Principal Scientist, Other , Durham, North Carolina

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