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Associate Scientist - Therapeutic Discovery

Company: Precision BioSciences
Location: Durham
Posted on: December 5, 2019

Job Description:

The Associate Scientist is responsible for the design and execution of experiments to further characterize and understand the mechanism of action of ARCUS nucleases in mammalian cell systems. The Associate Scientist will also apply this knowledge to developing improved applications of ARCUS technology. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. As a member of the Therapeutic Discovery Team, the Associate Scientist will: Conduct experiments to understand the mechanism of action of ARCUS nucleases within mammalian systems Apply cell biology understanding to aid in the design and testing of improved nucleases Design experimental approaches to understand DNA repair pathways in the context of ARCUS nuclease Define pathways involved in potential toxicity of nuclease overexpression Utilize ARCUS Nucleases to generate proof-of-concept data demonstrating therapeutic approach or mode of action in model system Define disease-specific cell signaling pathways and explore ARCUS-based modification of pathways for therapeutic application Report results to Therapeutic Discovery team File reports for internal use and for partners Generate graphs, slides, protocols and other documents for partners Present at lab meetings Participate in conference calls with partners/clients as needed Publish results as appropriate Share potential intellectual property developments with CSO and Patent Attorney/Agent Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Education/Experience The Associate Scientist will have a PhD in Biological Science (or equivalent) with 0-2 years of relevant experience in the following areas: Plasmid and genomic DNA isolation RNA isolation Molecular Cloning techniques for Vector construction PCR, qPCR DNA Sequencing Cell Culture DNA, RNA Transfection and Viral Transduction for expression in Eukaryotic Cells Systems Gene editing Protein Characterization by Western, Flow Cytometry, and ELISA Cell Based Assay development Work Environment The work environment characteristics described here are representative of those an employee could potentially encounter while performing the essential functions of this job. While performing the duties of this job, the employee is occasionally exposed to work near moving mechanical parts and fumes or airborne particles. The noise level in the work environment is usually moderate. Physical Demands The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. The employee must occasionally lift and/or move up to 50 pounds. Specific vision abilities required by this job include close vision, distance vision and depth perception. While performing the duties of this Job, the employee is regularly required to stand; walk; sit; use hands to finger, handle, or feel; reach with hands and arms and talk or hear. Travel Requirements This position requires little travel. Precision BioSciences is dedicated to improving life through its proprietary genome editing platform, ARCUS. Precision BioSciences leverages ARCUS in the development of its product candidates which are designed to treat human diseases and create healthy and sustainable food and agriculture solutions. Precision BioSciences is actively developing product candidates in three innovative areas: allogeneic CAR T immunotherapy, in vivo gene correction, and food. Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

Keywords: Precision BioSciences, Durham , Associate Scientist - Therapeutic Discovery, Other , Durham, North Carolina

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